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Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.

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Title: Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.
Authors: Sanford SL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Badstübner M; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA., Gerber M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Mannherz W; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lampl N; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Dannenberg R; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Hinchie A; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Schaich MA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Myong S; Program in Cell, Molecular, Developmental Biology and Biophysics, Johns Hopkins University, Baltimore, MD, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Agarwal S; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Alder JK; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Stone MD; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.; RNA Center, University of California Santa Cruz, Santa Cruz, CA, USA., Opresko PL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. plo4@pitt.edu.
Source: Nature communications [Nat Commun] 2025 Dec 07; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.
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  Data: <searchLink fieldCode="AU" term="%22Sanford+SL%22">Sanford SL</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Badstübner+M%22">Badstübner M</searchLink>; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gerber+M%22">Gerber M</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mannherz+W%22">Mannherz W</searchLink>; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lampl+N%22">Lampl N</searchLink>; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dannenberg+R%22">Dannenberg R</searchLink>; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hinchie+A%22">Hinchie A</searchLink>; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schaich+MA%22">Schaich MA</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Myong+S%22">Myong S</searchLink>; Program in Cell, Molecular, Developmental Biology and Biophysics, Johns Hopkins University, Baltimore, MD, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hedglin+M%22">Hedglin M</searchLink>; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Agarwal+S%22">Agarwal S</searchLink>; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alder+JK%22">Alder JK</searchLink>; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Stone+MD%22">Stone MD</searchLink>; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.; RNA Center, University of California Santa Cruz, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Opresko+PL%22">Opresko PL</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. plo4@pitt.edu.
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