Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.

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Bibliographic Details
Title: Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.
Authors: Mao L; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Liao ZF; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Tang D; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Qiu Y; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Yang M; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China., Li Y; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China., Xie Y; Department of Neurosurgery, the Affiliated Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong 516003, P.R. China., Feng W; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Zheng ZJ; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Liu XM; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Ye JR; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Lu SH; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Tang XB; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Shi M; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China., Qu YF; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China., Li H; Department of Cardiovascularology, Dongguan Tungwah Hospital, Dongguan, 523808, P.R. China., Wu ZG; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China., Xu S; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Liu X; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Ding J; RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, P.R. China., Xie JJ; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Tao J; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Xiong XD; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
Source: Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (3), pp. 1386-1409. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1838-7640
DOI:10.7150/thno.119709