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Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.

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Title: Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.
Authors: Mao L; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Liao ZF; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Tang D; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Qiu Y; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Yang M; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China., Li Y; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China., Xie Y; Department of Neurosurgery, the Affiliated Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong 516003, P.R. China., Feng W; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Zheng ZJ; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Liu XM; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Ye JR; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Lu SH; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Tang XB; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Shi M; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China., Qu YF; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China., Li H; Department of Cardiovascularology, Dongguan Tungwah Hospital, Dongguan, 523808, P.R. China., Wu ZG; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China., Xu S; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China., Liu X; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Ding J; RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, P.R. China., Xie JJ; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China., Tao J; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Xiong XD; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
Source: Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (3), pp. 1386-1409. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
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  Data: Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation.
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  Data: <searchLink fieldCode="AU" term="%22Mao+L%22">Mao L</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liao+ZF%22">Liao ZF</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Tang+D%22">Tang D</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Qiu+Y%22">Qiu Y</searchLink>; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Department of Neurosurgery, the Affiliated Huizhou First Hospital, Guangdong Medical University, Huizhou, Guangdong 516003, P.R. China.<br /><searchLink fieldCode="AU" term="%22Feng+W%22">Feng W</searchLink>; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zheng+ZJ%22">Zheng ZJ</searchLink>; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+XM%22">Liu XM</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ye+JR%22">Ye JR</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lu+SH%22">Lu SH</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Tang+XB%22">Tang XB</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.<br /><searchLink fieldCode="AU" term="%22Qu+YF%22">Qu YF</searchLink>; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Cardiovascularology, Dongguan Tungwah Hospital, Dongguan, 523808, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wu+ZG%22">Wu ZG</searchLink>; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ding+J%22">Ding J</searchLink>; RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xie+JJ%22">Xie JJ</searchLink>; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.<br /><searchLink fieldCode="AU" term="%22Tao+J%22">Tao J</searchLink>; Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xiong+XD%22">Xiong XD</searchLink>; Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.; Dongguan Key Laboratory of Aging and Anti-Aging, Institute of Aging Research, Guangdong Medical University, Dongguan, P.R. China.; Institute of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, P.R. China.; Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
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  Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2026 Jan 01; Vol. 16 (3), pp. 1386-1409. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101552395 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1838-7640 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218387640%22">18387640 </searchLink><i>NLM ISO Abbreviation: </i>Theranostics <i>Subsets: </i>MEDLINE
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