Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo.

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Title: Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo.
Authors: Birappa G; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea., Perumalsamy H; Center for Creative Convergence Education, Hanyang University, Seoul 04763, Republic of Korea.; Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea., Hong SH; Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Republic of Korea., Gowda DAA; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea., Chandrasekaran AP; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea., Karapurkar JK; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea., Rajkumar S; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea., Balusamy SR; Department of Food Science and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Republic of Korea., Jayachandran A; Fiona Elsey Cancer Research Institute, VIC, Australia.; Federation University, VIC, Australia., Baek KH; Department of Biomedical Science, CHA University, Gyeonggi-Do 13488, Republic of Korea., Lee J; Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea., Matam V; Department of Biotechnology, Alliance School of Applied Engineering, Alliance University, Bengaluru 562106, India., Kim WJ; Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea., Kim KS; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.; College of Medicine, Hanyang University, Seoul, 04763, South Korea., Ramakrishna S; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.; College of Medicine, Hanyang University, Seoul, 04763, South Korea., Suresh B; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.
Source: Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (2), pp. 986-1005. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1838-7640
DOI:10.7150/thno.117900