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(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.

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Title: (±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.
Authors: Guccione S; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Merlo S; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Tagliapietra S; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Pappalardo M; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Binello A; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Barge A; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Basile L; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Sortino MA; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy., Cravotto G; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Copani A; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2026 Jan 07; Vol. 17 (1), pp. 173-181. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-7193
DOI:10.1021/acschemneuro.5c00712