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(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.

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Title: (±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.
Authors: Guccione S; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Merlo S; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Tagliapietra S; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Pappalardo M; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Binello A; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Barge A; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Basile L; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy., Sortino MA; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy., Cravotto G; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy., Copani A; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2026 Jan 07; Vol. 17 (1), pp. 173-181. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: (±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Guccione+S%22">Guccione S</searchLink>; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Merlo+S%22">Merlo S</searchLink>; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Tagliapietra+S%22">Tagliapietra S</searchLink>; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Pappalardo+M%22">Pappalardo M</searchLink>; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Binello+A%22">Binello A</searchLink>; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Barge+A%22">Barge A</searchLink>; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Basile+L%22">Basile L</searchLink>; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Sortino+MA%22">Sortino MA</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Cravotto+G%22">Cravotto G</searchLink>; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Copani+A%22">Copani A</searchLink>; Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101525337%22">ACS chemical neuroscience</searchLink> [ACS Chem Neurosci] 2026 Jan 07; Vol. 17 (1), pp. 173-181. <i>Date of Electronic Publication: </i>2025 Dec 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101525337 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1948-7193 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219487193%22">19487193 </searchLink><i>NLM ISO Abbreviation: </i>ACS Chem Neurosci <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acschemneuro.5c00712
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      – TitleFull: (±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.
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              Text: 2026 Jan 07
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