Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination.
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| Title: | Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination. |
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| Authors: | Cao X; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Manhas A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Chen YI; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Caudal A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Mondejar-Parreño G; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhu W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Kong X; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zeng W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu L; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhao SR; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Jahng JWS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Utz PJ; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Nadeau KC; Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Department of Medicine and Division of Allergy and Inflammation, Beth Israel Deaconess Hospital, Boston, MA 02215, USA., Nishiga M; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Greenstone Biosciences, Palo Alto, CA 94304, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Dec 10; Vol. 17 (828), pp. eadq0143. Date of Electronic Publication: 2025 Dec 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adq0143 |
