ZAP327 signaling domain-driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models.
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| Title: | ZAP327 signaling domain-driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models. |
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| Authors: | Liu X; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA., Zhang J; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Chu J; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Chen YJ; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Qian C; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Wang HY; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA., Wang RF; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Dec 10; Vol. 17 (828), pp. eadz0529. Date of Electronic Publication: 2025 Dec 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adz0529 |
