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Andrographolide-induced PANoptosis underlies its multiple organ toxicity in mice.

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Title: Andrographolide-induced PANoptosis underlies its multiple organ toxicity in mice.
Authors: Lu N; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China., Cai YW; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China., Cai QH; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Center of Reproductive Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China., Liang XW; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China., Sun N; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China., Chan OK; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China., Shi ZJ; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China., Hu B; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China., He XH; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. Electronic address: thexh@jnu.edu.cn., Zha QB; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China; Center of Reproductive Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China. Electronic address: zhaqingbb@sina.com., Ouyang DY; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. Electronic address: dongyun1967@aliyun.com.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Feb; Vol. 507, pp. 117682. Date of Electronic Publication: 2025 Dec 08.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Andrographolide-induced PANoptosis underlies its multiple organ toxicity in mice.
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  Data: <searchLink fieldCode="AU" term="%22Lu+N%22">Lu N</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China.<br /><searchLink fieldCode="AU" term="%22Cai+YW%22">Cai YW</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China.<br /><searchLink fieldCode="AU" term="%22Cai+QH%22">Cai QH</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Center of Reproductive Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Liang+XW%22">Liang XW</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China.<br /><searchLink fieldCode="AU" term="%22Sun+N%22">Sun N</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China.<br /><searchLink fieldCode="AU" term="%22Chan+OK%22">Chan OK</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China.<br /><searchLink fieldCode="AU" term="%22Shi+ZJ%22">Shi ZJ</searchLink>; Department of Fetal Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Nephrology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22He+XH%22">He XH</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. Electronic address: thexh@jnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zha+QB%22">Zha QB</searchLink>; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China; Center of Reproductive Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China. Electronic address: zhaqingbb@sina.com.<br /><searchLink fieldCode="AU" term="%22Ouyang+DY%22">Ouyang DY</searchLink>; Department of Immunology and Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, the Sixth Affiliated Hospital of Jinan University, Dongguan, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, the Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. Electronic address: dongyun1967@aliyun.com.
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  Data: <searchLink fieldCode="JN" term="%220416575%22">Toxicology and applied pharmacology</searchLink> [Toxicol Appl Pharmacol] 2026 Feb; Vol. 507, pp. 117682. <i>Date of Electronic Publication: </i>2025 Dec 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0416575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0333 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220041008X%22">0041008X </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Appl Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.taap.2025.117682
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        Text: English
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              Text: 2026 Feb
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