Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies.

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Title: Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies.
Authors: Rassner M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Müller TA; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department I of Internal Medicine, Center for Integrated Oncology, Aachen-Bonn-Cologne-Duesseldorf, University of Cologne, Cologne, Germany., Crossley KA; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schaberg S; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Endres C; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Jakob L; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Poggio T; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Köhler N; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany., Kolter J; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Infection Prevention and Control, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Müller-Newen G; Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany., Schönberger K; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Cabezas-Wallscheid N; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Gonzalez-Menendez I; Department of Pathology and Neuropathology, University Hospital Tübingen & Comprehensive Cancer Center Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard-Karls University of Tübingen, Tübingen, Germany., Quintanilla-Martinez L; Department of Pathology and Neuropathology, University Hospital Tübingen & Comprehensive Cancer Center Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard-Karls University of Tübingen, Tübingen, Germany., Zwick M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ashok D; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Hartmann TN; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Groß O; CIBSS - Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany.; Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gorka O; Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Follo M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Illert AL; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany.; Medical Department for Hematology and Oncology, Klinikum Rechts der Isar, Technische Universität München, München, Germany.; Department of Hematology and Medical Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Zeiser R; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Duyster J; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. justus.duyster@uniklinik-freiburg.de.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany. justus.duyster@uniklinik-freiburg.de.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Dec 11; Vol. 10 (1), pp. 400. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-025-02491-6