Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.
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| Title: | Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis. |
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| Authors: | Ojo BA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Zhu Y; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Heo L; Stanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA., Fox SR; Applied Gene and Cell Therapy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Qiao Y; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Waddell A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Moreno-Fernandez ME; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Gibson M; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Tran T; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Dunn AL; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Elknawy EIA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Saini N; Division of Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., López-Rivera JA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Dai Y; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., de Jesus Perez VA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA., Rosen MJ; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA. rosenm@stanford.edu.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA. rosenm@stanford.edu. |
| Source: | Nature communications [Nat Commun] 2025 Dec 10; Vol. 16 (1), pp. 11026. Date of Electronic Publication: 2025 Dec 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65988-2 |
