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Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.

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Title: Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.
Authors: Ojo BA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Zhu Y; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Heo L; Stanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA., Fox SR; Applied Gene and Cell Therapy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Qiao Y; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Waddell A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Moreno-Fernandez ME; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Gibson M; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Tran T; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Dunn AL; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Elknawy EIA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Saini N; Division of Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., López-Rivera JA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA., Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Dai Y; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., de Jesus Perez VA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA., Rosen MJ; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA. rosenm@stanford.edu.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA. rosenm@stanford.edu.
Source: Nature communications [Nat Commun] 2025 Dec 10; Vol. 16 (1), pp. 11026. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis.
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  Data: <searchLink fieldCode="AU" term="%22Ojo+BA%22">Ojo BA</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Heo+L%22">Heo L</searchLink>; Stanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fox+SR%22">Fox SR</searchLink>; Applied Gene and Cell Therapy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Qiao+Y%22">Qiao Y</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Waddell+A%22">Waddell A</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Moreno-Fernandez+ME%22">Moreno-Fernandez ME</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+M%22">Gibson M</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+T%22">Tran T</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+AL%22">Dunn AL</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Elknawy+EIA%22">Elknawy EIA</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saini+N%22">Saini N</searchLink>; Division of Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22López-Rivera+JA%22">López-Rivera JA</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Divanovic+S%22">Divanovic S</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dai+Y%22">Dai Y</searchLink>; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22de+Jesus+Perez+VA%22">de Jesus Perez VA</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+MJ%22">Rosen MJ</searchLink>; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University School of Medicine, Stanford, CA, USA. rosenm@stanford.edu.; Center for IBD and Celiac Disease, Stanford Medicine Children's Health, Palo Alto, CA, USA. rosenm@stanford.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 10; Vol. 16 (1), pp. 11026. <i>Date of Electronic Publication: </i>2025 Dec 10.
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