Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women.

Saved in:
Bibliographic Details
Title: Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women.
Authors: Guare LA; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States., Das J; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States., Caruth L; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States., Rajagopalan A; Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, United States., Akerele AT; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, and Meharry Medical College, Nashville, TN, United States., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway., Chen TT; Center for Neuropsychiatric Research, National Health Research Institutes, Maoli County, Taiwan., Kottyan L; Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States., Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Maoli County, Taiwan., Moreno E; HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway., Mulford AJ; Endeavor Health, Evanston, IL, United States., Dombrovska MS; Latvian Biomedical Research and Study Centre, Riga, Latvia., Luo Y; Feinberg School of Medicine, Northwestern University, Chicago, IL, United States., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Sanders AR; Endeavor Health, Evanston, IL, United States., Teerlink C; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States., Candelieri D; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States., Elhadad N; Biomedical Informatics, Columbia University, New York City, NY, United States., Hill A; Colorado for Precision Medicine, Aurora, CO, United States., Jarvik GP; Division of Medical Genetics, University of Washington, Seattle, WA, United States., Jaworski J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Lynch J; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States., Namba S; Genome Informatics, The University of Tokyo, Tokyo, Japan., Okada Y; Genome Informatics, The University of Tokyo, Tokyo, Japan., Shi Y; Broad Institute, Cambridge, MA, United States., Shirai Y; Statistical Genetics, Osaka University, Suita, Osaka, Japan., Shortt J; Colorado for Precision Medicine, Aurora, CO, United States., Wei WQ; Biomedical Informatics, Vanderbilt University, Nashville, TN, United States., Weng C; Biomedical Informatics, Columbia University, New York City, NY, United States., Yamamoto Y; Statistical Genetics, Osaka University, Suita, Osaka, Japan., Biobank PM; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, and Meharry Medical College, Nashville, TN, United States.; HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Center for Neuropsychiatric Research, National Health Research Institutes, Maoli County, Taiwan.; Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States.; Endeavor Health, Evanston, IL, United States.; Latvian Biomedical Research and Study Centre, Riga, Latvia.; Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States.; Biomedical Informatics, Columbia University, New York City, NY, United States.; Colorado for Precision Medicine, Aurora, CO, United States.; Division of Medical Genetics, University of Washington, Seattle, WA, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Genome Informatics, The University of Tokyo, Tokyo, Japan.; Broad Institute, Cambridge, MA, United States.; Statistical Genetics, Osaka University, Suita, Osaka, Japan.; Biomedical Informatics, Vanderbilt University, Nashville, TN, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Genetics Center R; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, and Meharry Medical College, Nashville, TN, United States.; HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Center for Neuropsychiatric Research, National Health Research Institutes, Maoli County, Taiwan.; Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States.; Endeavor Health, Evanston, IL, United States.; Latvian Biomedical Research and Study Centre, Riga, Latvia.; Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States.; Biomedical Informatics, Columbia University, New York City, NY, United States.; Colorado for Precision Medicine, Aurora, CO, United States.; Division of Medical Genetics, University of Washington, Seattle, WA, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Genome Informatics, The University of Tokyo, Tokyo, Japan.; Broad Institute, Cambridge, MA, United States.; Statistical Genetics, Osaka University, Suita, Osaka, Japan.; Biomedical Informatics, Vanderbilt University, Nashville, TN, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Meta-Analysis Initiative GB; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, and Meharry Medical College, Nashville, TN, United States.; HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.; Center for Neuropsychiatric Research, National Health Research Institutes, Maoli County, Taiwan.; Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States.; Endeavor Health, Evanston, IL, United States.; Latvian Biomedical Research and Study Centre, Riga, Latvia.; Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.; VA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salte Lake City, UT, United States.; Biomedical Informatics, Columbia University, New York City, NY, United States.; Colorado for Precision Medicine, Aurora, CO, United States.; Division of Medical Genetics, University of Washington, Seattle, WA, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.; Genome Informatics, The University of Tokyo, Tokyo, Japan.; Broad Institute, Cambridge, MA, United States.; Statistical Genetics, Osaka University, Suita, Osaka, Japan.; Biomedical Informatics, Vanderbilt University, Nashville, TN, United States.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Chapman S; Broad Institute, Cambridge, MA, United States., Zhou W; Broad Institute, Cambridge, MA, United States., Edwards T; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Senapati S; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States., Velez Edwards DR; Division of Quantitative Science, Department of Obstetrics and Gynecology, Department of Microbiology, Immunology, and Physiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States., Setia-Verma S; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Source: Research square [Res Sq] 2025 Dec 04. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-8116602/v1