Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus.

Saved in:
Bibliographic Details
Title: Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus.
Authors: Shubert NMA; Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands., Yao S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Naeini MK; Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK., Trpchevska N; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden., Bishop C; Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA., Bizaki-Vallaskangas A; Tampere University, Faculty of Medicine and Health Technology, Department of Otolaryngology, Tampere, Finland.; Pirkanmaan hyvinvointialue, Department of Ear and Oral Diseases, Tampere, Finland., Broer L; Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Castellana F; Unit of Epidemiology and Statistics, Local Health Authority of Taranto, Taranto, Italy., Christensen K; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark., Hjelmborg JVB; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark., Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy., Santin A; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy.; Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy., Girotto G; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy.; Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy., Nardone GG; Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy., Iacoviello L; Department of Epidemiology and Prevention, I.R.C.C.S. Neuromed, Pozzilli, Italy.; Department of Medicine and Surgery, LUM University, Casamassima, Italy., Mengel-From J; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark., Gallagher S; Decibel Therapeutics Inc., Gudjonsson A; Icelandic Heart Association, 201 Kopavogur, Iceland., Gudnason V; Icelandic Heart Association, 201 Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Heard-Costa NL; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.; Framingham Heart Study, Framingham, MA 01702, USA., Seshadri S; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.; Framingham Heart Study, Framingham, MA 01702, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Population Health Sciences, University of Texas Health Sciences Center, San Antonio, TX 78229, USA., Hoffman HJ; Epidemiology, Statistics, and Population Sciences, National Institute on Deafness and Other Communications Disorders (NIDCD), NIH, Bethesda, MD 20892, USA., Li CM; Epidemiology, Statistics, and Population Sciences, National Institute on Deafness and Other Communications Disorders (NIDCD), NIH, Bethesda, MD 20892, USA., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Rämö J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Saarentaus E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Kettunen J; Systems medicine, Research unit of Population Health, University of Oulu, 90220 Oulu, Finland.; Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.; Finnish Institute for Health and Welfare, 00271 Helsinki, Finland., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kähler AK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Launer LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program National Institute on Aging, Bethesda, MD 20892, USA., Leonard H; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, Bethesda, MD 20892, USA.; Data Tecnica, Washington DC, 20037, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, Bethesda, MD 20892, USA.; Data Tecnica, Washington DC, 20037, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., van Meurs J; Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mäkitie A; Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS, Helsinki, Finland., Oosterloo BC; Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Nygaard M; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark., Palviainen T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Pratt S; Department of Communication Science & Disorders, University of Pittsburgh, Pittsburgh, Pa 15260, USA., Quaranta N; Otolaryngology Unit, Department of Translational Biomedicine and Neuroscience (DiBrain), University of Bari, Policlinico di Bari, Italy., Sardone R; Unit of Epidemiology and Statistics, Local Health Authority of Taranto, Taranto, Italy., Satizabal CL; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.; Framingham Heart Study, Framingham, MA 01702, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Population Health Sciences, University of Texas Health Sciences Center, San Antonio, TX 78229, USA., Schweinfurth JM; Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA., Shiroma E; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA., Simonsick E; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Spankovich C; Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27516, USA., Goedegebure A; Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Nagtegaal AP; Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Pyott SJ; Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands.; Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany., Cederroth CR; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.; Department of Otolaryngology, Head & Neck Surgery, University of Tübingen Medical Center, 72076 Tübingen, Germany., Freidin MB; Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK., Williams FM; Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK.
Corporate Authors: Estonian Biobank Research Team, Lifelines Cohort Study
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Dec 01. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.11.28.25340151