The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.

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Title: The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.
Authors: Kittane S; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Ladewig E; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Li T; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Love JR; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Blawski R; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Gao Y; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Arruabarrena-Aristorena A; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Bilbao, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Zhao P; Department of Oncology, KU Leuven, Leuven, Belgium., Dalrymple SL; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Liu H; AstraZeneca, Gaithersburg, Maryland., Guo X; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Sallaku M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Kelkar N; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Garcia-Martinez L; Sylvester Comprehensive Cancer Center, Miami, Florida., Carmona Sanz J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Chen W; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Stoudmann C; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Baldino L; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Razavi-Mohseni M; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Kalemi I; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Beer MA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Castel P; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York., Brennen WN; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland., Scaltriti M; AstraZeneca, Gaithersburg, Maryland., Morey L; Sylvester Comprehensive Cancer Center, Miami, Florida., Cocco E; Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, Florida., Ji H; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Chan HM; AstraZeneca, Gaithersburg, Maryland., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Karthaus WR; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland., Toska E; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland.
Source: Cancer research [Cancer Res] 2026 Mar 02; Vol. 86 (5), pp. 1113-1131.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-25-2053