Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.
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| Title: | Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes. |
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| Authors: | Krupina K; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Goginashvili A; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Baughn MW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Moore S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Steele CD; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA., Nguyen AT; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Zhang DL; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Koeppel J; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK., Trivedi P; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Malhotra A; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Jenkins D; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA., Shiau AK; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA., Miyake Y; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA., Koga T; Department of Medicine, University of California at San Diego, La Jolla, USA., Miki S; Department of Medicine, University of California at San Diego, La Jolla, USA., Furnari FB; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA.; Department of Medicine, University of California at San Diego, La Jolla, USA., Campbell PJ; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA., Cleveland DW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA. |
| Source: | Science (New York, N.Y.) [Science] 2025 Dec 11; Vol. 390 (6778), pp. 1156-1163. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.ado0977 |
