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Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.

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Title: Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.
Authors: Krupina K; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Goginashvili A; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Baughn MW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Moore S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Steele CD; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA., Nguyen AT; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Zhang DL; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Koeppel J; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK., Trivedi P; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Malhotra A; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA., Jenkins D; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA., Shiau AK; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA., Miyake Y; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA., Koga T; Department of Medicine, University of California at San Diego, La Jolla, USA., Miki S; Department of Medicine, University of California at San Diego, La Jolla, USA., Furnari FB; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA.; Department of Medicine, University of California at San Diego, La Jolla, USA., Campbell PJ; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK., Alexandrov LB; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA., Cleveland DW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.
Source: Science (New York, N.Y.) [Science] 2025 Dec 11; Vol. 390 (6778), pp. 1156-1163. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.
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  Data: <searchLink fieldCode="AU" term="%22Krupina+K%22">Krupina K</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Goginashvili+A%22">Goginashvili A</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Baughn+MW%22">Baughn MW</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Moore+S%22">Moore S</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Steele+CD%22">Steele CD</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+AT%22">Nguyen AT</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+DL%22">Zhang DL</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Koeppel+J%22">Koeppel J</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Trivedi+P%22">Trivedi P</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+A%22">Malhotra A</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+D%22">Jenkins D</searchLink>; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Shiau+AK%22">Shiau AK</searchLink>; Department of Cell and Developmental Biology, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Miyake+Y%22">Miyake Y</searchLink>; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Koga+T%22">Koga T</searchLink>; Department of Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Miki+S%22">Miki S</searchLink>; Department of Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Furnari+FB%22">Furnari FB</searchLink>; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA.; Department of Medicine, University of California at San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Center, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Department of Bioengineering, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Cleveland+DW%22">Cleveland DW</searchLink>; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, USA.; Moores Cancer Center, University of California at San Diego, La Jolla, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2025 Dec 11; Vol. 390 (6778), pp. 1156-1163. <i>Date of Electronic Publication: </i>2025 Dec 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
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