Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics.

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Bibliographic Details
Title: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics.
Authors: Avraham-Davidi I; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Mages S; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States.; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany., Klughammer J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States.; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany., Moriel N; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Imada S; Departmen of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, United States., Hofree M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Murray E; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States., Chen J; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, United States.; Department of Pathology, MGH, Boston, United States., Pelka K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, United States., Mehta A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, United States.; Dana-Farber Cancer Institute, Boston, United States., Boland GM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Department of Surgery, MGH, Boston, United States., Delorey T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Caplan L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Strasser R; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany., Lalakova J; 10xGenomics, Stockholm, Sweden., Niesnerova A; 10xGenomics, Stockholm, Sweden., Xu H; 10xGenomics, Stockholm, Sweden., Rouault M; 10xGenomics, Stockholm, Sweden., Tirosh I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Nir H; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, United States., Chen F; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, United States.; Harvard Stem Cell and Regenerative Biology, Cambridge, United States., Yilmaz O; Departmen of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, United States.; Department of Pathology, Massachusetts General Hospital, Boston, United States., Roper J; Departmen of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, United States., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States., Nitzan M; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Racah Institute of Physics and Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, United States.; Departmen of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, United States.
Source: ELife [Elife] 2025 Dec 12; Vol. 14. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2050-084X
DOI:10.7554/eLife.104815