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VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study.

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Title: VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study.
Authors: Guo C; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Yang Q; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Deng M; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Qiu X; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Wu S; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Du X; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Sai K; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Dai Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Chen Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Zhang J; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Lin F; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Ke C; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Xi S; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Hu W; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Zhou Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Li J; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Cao X; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Liao Y; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Lv Y; Department of Radiology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Brown D; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA. dbrown@valenttech.com.; Valent Technologies, LLC, Menlo Park, CA, USA. dbrown@valenttech.com.; Edison Oncology Holding Corp., Menlo Park, CA, USA. dbrown@valenttech.com., Langlands J; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Valent Technologies, LLC, Menlo Park, CA, USA., Johnson G; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Bacha J; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Edison Oncology Holding Corp., Menlo Park, CA, USA., Kwan C; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Kanekal S; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Schwartz R; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Chen Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China. chenzhp@sysucc.org.cn.
Source: Discover oncology [Discov Oncol] 2025 Dec 12; Vol. 17 (1), pp. 104. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2730-6011
DOI:10.1007/s12672-025-04235-y