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VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study.

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Title: VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study.
Authors: Guo C; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Yang Q; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Deng M; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Qiu X; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Wu S; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Du X; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Sai K; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Dai Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Chen Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Zhang J; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Lin F; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Ke C; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Xi S; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Hu W; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Zhou Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Li J; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Cao X; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Liao Y; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Lv Y; Department of Radiology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China., Brown D; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA. dbrown@valenttech.com.; Valent Technologies, LLC, Menlo Park, CA, USA. dbrown@valenttech.com.; Edison Oncology Holding Corp., Menlo Park, CA, USA. dbrown@valenttech.com., Langlands J; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Valent Technologies, LLC, Menlo Park, CA, USA., Johnson G; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Bacha J; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Edison Oncology Holding Corp., Menlo Park, CA, USA., Kwan C; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Kanekal S; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Schwartz R; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA., Chen Z; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China. chenzhp@sysucc.org.cn.
Source: Discover oncology [Discov Oncol] 2025 Dec 12; Vol. 17 (1), pp. 104. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study.
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  Data: <searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Deng+M%22">Deng M</searchLink>; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Qiu+X%22">Qiu X</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; Department of Radiation Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Sai+K%22">Sai K</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lin+F%22">Lin F</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ke+C%22">Ke C</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xi+S%22">Xi S</searchLink>; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Department of Pathology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lv+Y%22">Lv Y</searchLink>; Department of Radiology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Brown+D%22">Brown D</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA. dbrown@valenttech.com.; Valent Technologies, LLC, Menlo Park, CA, USA. dbrown@valenttech.com.; Edison Oncology Holding Corp., Menlo Park, CA, USA. dbrown@valenttech.com.<br /><searchLink fieldCode="AU" term="%22Langlands+J%22">Langlands J</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Valent Technologies, LLC, Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+G%22">Johnson G</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bacha+J%22">Bacha J</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.; Edison Oncology Holding Corp., Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kwan+C%22">Kwan C</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kanekal+S%22">Kanekal S</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schwartz+R%22">Schwartz R</searchLink>; DelMar Pharmaceuticals, Inc., Vancouver, Menlo Park, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurosurgery/Neuro-Oncology, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China. chenzhp@sysucc.org.cn.
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