Assessment of the therapeutic efficacy of rutin-loaded PLGA nanocapsule-based gel against imiquimod-induced psoriasis model using box-behnken design for optimization.
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| Title: | Assessment of the therapeutic efficacy of rutin-loaded PLGA nanocapsule-based gel against imiquimod-induced psoriasis model using box-behnken design for optimization. |
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| Authors: | Husseini RA; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: rabab.ahmed@zu.edu.eg., Emam SE; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: shea@zu.edu.eg., Abd El Razek AM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: amalmagdy@zu.edu.eg., Hamed E; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. Electronic address: eslam.hamed@zu.edu.eg., Elshamy AI; Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza 12622, Egypt. Electronic address: ai.el-shamy@nrc.sci.eg., Abdelnabi DM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: dinaabdelnabi@zu.edu.eg. |
| Source: | International journal of pharmaceutics [Int J Pharm] 2026 Jan 20; Vol. 689, pp. 126458. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2025.126458 |
