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Assessment of the therapeutic efficacy of rutin-loaded PLGA nanocapsule-based gel against imiquimod-induced psoriasis model using box-behnken design for optimization.

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Title: Assessment of the therapeutic efficacy of rutin-loaded PLGA nanocapsule-based gel against imiquimod-induced psoriasis model using box-behnken design for optimization.
Authors: Husseini RA; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: rabab.ahmed@zu.edu.eg., Emam SE; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: shea@zu.edu.eg., Abd El Razek AM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: amalmagdy@zu.edu.eg., Hamed E; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. Electronic address: eslam.hamed@zu.edu.eg., Elshamy AI; Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza 12622, Egypt. Electronic address: ai.el-shamy@nrc.sci.eg., Abdelnabi DM; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: dinaabdelnabi@zu.edu.eg.
Source: International journal of pharmaceutics [Int J Pharm] 2026 Jan 20; Vol. 689, pp. 126458. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Husseini+RA%22">Husseini RA</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: rabab.ahmed@zu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Emam+SE%22">Emam SE</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: shea@zu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abd+El+Razek+AM%22">Abd El Razek AM</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: amalmagdy@zu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Hamed+E%22">Hamed E</searchLink>; Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt. Electronic address: eslam.hamed@zu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elshamy+AI%22">Elshamy AI</searchLink>; Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza 12622, Egypt. Electronic address: ai.el-shamy@nrc.sci.eg.<br /><searchLink fieldCode="AU" term="%22Abdelnabi+DM%22">Abdelnabi DM</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: dinaabdelnabi@zu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%227804127%22">International journal of pharmaceutics</searchLink> [Int J Pharm] 2026 Jan 20; Vol. 689, pp. 126458. <i>Date of Electronic Publication: </i>2025 Dec 11.
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      – TitleFull: Assessment of the therapeutic efficacy of rutin-loaded PLGA nanocapsule-based gel against imiquimod-induced psoriasis model using box-behnken design for optimization.
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              Text: 2026 Jan 20
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