Histamine N-methyltransferase inhibition as a novel therapeutic strategy for idiopathic hypersomnia.

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Bibliographic Details
Title: Histamine N-methyltransferase inhibition as a novel therapeutic strategy for idiopathic hypersomnia.
Authors: Girgin B; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Naganuma F; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Hirano K; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Fujiya M; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Mimura T; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Ebina R; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Zhu R; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Nishibe A; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Nakamura T; Division of Bioregulatory Pharmacology, Department of Pharmacology, Iwate Medical University, Japan., Vetrivelan R; Department of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Miyoshi C; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Japan., Mochizuki T; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Japan., Funato H; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Japan., Watanabe M; Department of Anatomy, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Japan., Yoshikawa T; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Electronic address: tyoshikawa@pop.med.hokudai.ac.jp.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jan 12; Vol. 1011, pp. 178475. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0712
DOI:10.1016/j.ejphar.2025.178475