Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair.

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Title: Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair.
Authors: Jiang Y; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Przybilla M; Wellcome Sanger Institute, Hinxton, UK., Bakker L; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Jacobs FC; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Mckeon D; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., van der Sluijs R; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Sato K; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Wezenbeek J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., van Strien J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Willems J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Verkennis AEE; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Barnett J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Ortega AB; Wellcome Sanger Institute, Hinxton, UK., Abascal F; Wellcome Sanger Institute, Hinxton, UK., Villalta PW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Knipscheer P; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands., Martincorena I; Wellcome Sanger Institute, Hinxton, UK., Balbo S; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Garaycoechea J; Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. juan.g@hubrecht.eu.
Source: Nature communications [Nat Commun] 2025 Dec 12; Vol. 17 (1), pp. 436. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-67072-1