Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission.

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Title: Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission.
Authors: Dai R; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China., Zheng MM; Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Shi YN; Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Luo MH; Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang Y; Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China., Wang HW; Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Yu DQ; Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Chen QW; Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Lin L; Department of Geriatric Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. Electronic address: Kmulinling2017@163.com., Zhou JW; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address: 13910634708@163.com., Su ZD; Department of Geriatric Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China; Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China; Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: suzedazhong@ydyy.cn.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jan 15; Vol. 169, pp. 116019. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1705
DOI:10.1016/j.intimp.2025.116019