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Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors.

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Title: Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors.
Authors: Axten JM; GSK Research and Development 1250 S. Collegeville Road Collegeville Pennsylvania 19426 USA jeffrey.m.axten@gsk.com., Ding X; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Stasi LP; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Zhao B; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Sang Y; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Ho MH; GSK Research and Development 1250 S. Collegeville Road Collegeville Pennsylvania 19426 USA jeffrey.m.axten@gsk.com., Wang L; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Zhang M; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Guo X; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Tan C; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Feng X; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Edge C; GSK Research and Development Medicines Research Centre Gunnels Wood Road Stevenage SG1 2NY UK., Valko K; GSK Research and Development Medicines Research Centre Gunnels Wood Road Stevenage SG1 2NY UK., Li Y; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Dong K; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Guan X; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Zinn N; Omics Technologies, Cellzome a GSK Company Meyerhofstrasse 1 D-69117 Heidelberg Germany., David Tattersall F; GSK Research and Development 1250 S. Collegeville Road Collegeville Pennsylvania 19426 USA jeffrey.m.axten@gsk.com., Ren F; GSK Research and Development 898 Halei Road, Zhangjiang Hi-Tech Park Pudong Shanghai 201203 PR China., Su DS; GSK Research and Development 1250 S. Collegeville Road Collegeville Pennsylvania 19426 USA jeffrey.m.axten@gsk.com., Reith AD; GSK Research and Development Medicines Research Centre Gunnels Wood Road Stevenage SG1 2NY UK.
Source: RSC medicinal chemistry [RSC Med Chem] 2025 Nov 17. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem
Database: MEDLINE Ultimate
Description
ISSN:2632-8682
DOI:10.1039/d5md00856e