Apremilast ameliorates methotrexate-induced renal injury in rats: role of TLR4/NF-κB/P38 MAPK/caspase-3 and Nrf2/HO-1 signaling pathways.
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| Title: | Apremilast ameliorates methotrexate-induced renal injury in rats: role of TLR4/NF-κB/P38 MAPK/caspase-3 and Nrf2/HO-1 signaling pathways. |
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| Authors: | Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Sharata EE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Abdelnaser M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. mahmoud.abdelnaser@deraya.edu.eg., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.; Department of Pathology, Faculty of Medicine, Minia National University, Minia, 61519, Egypt., Kotb ASM; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Rofaeil RR; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt.; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Mar; Vol. 399 (5), pp. 7615-7629. Date of Electronic Publication: 2025 Dec 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-025-04846-w |
