Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
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| Title: | Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial. |
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| Authors: | Devanand DP; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York., Wisniewski T; Center for Cognitive Neurology, Department of Neurology, Grossman School of Medicine, New York University, New York, New York.; Departments of Pathology and Psychiatry, Grossman School of Medicine, New York University, New York, New York., Razlighi Q; Department of Radiology, Weill-Cornell Medical Center, New York, New York., Qian M; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York., Wei R; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York., Andrews HF; Department of Psychiatry, Columbia University Medical Center, New York, New York., Acosta EP; Department of Pharmacology, University of Alabama, Birmingham., Bell KL; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York., Pelton GH; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York., Deliyannides D; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York., Perrin AC; Banner Alzheimer's Institute, University of Arizona, Phoenix., Caccappolo E; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York., Gershon AA; Department of Pediatrics, Columbia University Medical Center, New York, New York., Prasad KM; Departments of Psychiatry and Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania.; VA Pittsburgh Health System, Pittsburgh, Pennsylvania., Kreisl WC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.; Currently employed by Eisai Inc, Nutley, New Jersey., Mintz A; Department of Radiology, Columbia University Medical Center, New York, New York., Huey ED; Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, Rhode Island. |
| Source: | JAMA [JAMA] 2026 Feb 10; Vol. 335 (6), pp. 511-522. |
| Publication Type: | Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.21738 |
