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Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.

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Title: Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
Authors: Devanand DP; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York., Wisniewski T; Center for Cognitive Neurology, Department of Neurology, Grossman School of Medicine, New York University, New York, New York.; Departments of Pathology and Psychiatry, Grossman School of Medicine, New York University, New York, New York., Razlighi Q; Department of Radiology, Weill-Cornell Medical Center, New York, New York., Qian M; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York., Wei R; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York., Andrews HF; Department of Psychiatry, Columbia University Medical Center, New York, New York., Acosta EP; Department of Pharmacology, University of Alabama, Birmingham., Bell KL; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York., Pelton GH; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York., Deliyannides D; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York., Perrin AC; Banner Alzheimer's Institute, University of Arizona, Phoenix., Caccappolo E; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York., Gershon AA; Department of Pediatrics, Columbia University Medical Center, New York, New York., Prasad KM; Departments of Psychiatry and Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania.; VA Pittsburgh Health System, Pittsburgh, Pennsylvania., Kreisl WC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.; Currently employed by Eisai Inc, Nutley, New Jersey., Mintz A; Department of Radiology, Columbia University Medical Center, New York, New York., Huey ED; Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, Rhode Island.
Source: JAMA [JAMA] 2026 Feb 10; Vol. 335 (6), pp. 511-522.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Devanand+DP%22">Devanand DP</searchLink>; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wisniewski+T%22">Wisniewski T</searchLink>; Center for Cognitive Neurology, Department of Neurology, Grossman School of Medicine, New York University, New York, New York.; Departments of Pathology and Psychiatry, Grossman School of Medicine, New York University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Razlighi+Q%22">Razlighi Q</searchLink>; Department of Radiology, Weill-Cornell Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Qian+M%22">Qian M</searchLink>; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wei+R%22">Wei R</searchLink>; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Andrews+HF%22">Andrews HF</searchLink>; Department of Psychiatry, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Acosta+EP%22">Acosta EP</searchLink>; Department of Pharmacology, University of Alabama, Birmingham.<br /><searchLink fieldCode="AU" term="%22Bell+KL%22">Bell KL</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pelton+GH%22">Pelton GH</searchLink>; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Deliyannides+D%22">Deliyannides D</searchLink>; Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, New York.; Department of Psychiatry, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Perrin+AC%22">Perrin AC</searchLink>; Banner Alzheimer's Institute, University of Arizona, Phoenix.<br /><searchLink fieldCode="AU" term="%22Caccappolo+E%22">Caccappolo E</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Gershon+AA%22">Gershon AA</searchLink>; Department of Pediatrics, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Prasad+KM%22">Prasad KM</searchLink>; Departments of Psychiatry and Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania.; VA Pittsburgh Health System, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kreisl+WC%22">Kreisl WC</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.; Currently employed by Eisai Inc, Nutley, New Jersey.<br /><searchLink fieldCode="AU" term="%22Mintz+A%22">Mintz A</searchLink>; Department of Radiology, Columbia University Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Huey+ED%22">Huey ED</searchLink>; Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, Rhode Island.
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