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Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation.

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Title: Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation.
Authors: Sagie S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel., Babu T; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Weller C; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Tabachnik C; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Livneh I; Rappaport Technion Cancer Research center, The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel; Institute of Pathology, Rambam Health Care Campus, Haifa 3109601, Israel., Quast NP; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK., Gumpert N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Shomuradova A; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK., Raybould MI; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK., Levy R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Malko D; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Alfia A; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Ben Lulu T; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Alon M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Herrera F; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Kutuzov M; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK., Zerbib M; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel., Greenberg P; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Wasserman-Bartov T; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Benedek G; Faculty of Medicine, Hadassah Hebrew-University Medical Center, Jerusalem 91120, Israel., Levin Y; INCPM, Weizmann Institute of Science, Rehovot 7610001, Israel., Stossel C; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel., Kamer I; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel., Golan T; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel., Oren R; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel., Shmueli M; Department of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Bartok O; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Bar J; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel., Cohen J; Sharett Institute of Oncology, Hadassah Cancer Research Institute and The Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel., Dushek O; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK., Deane CM; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK., Samuels Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: yardena.samuels@weizmann.ac.il.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Dec 16; Vol. 6 (12), pp. 102506.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation.
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  Data: <searchLink fieldCode="AU" term="%22Sagie+S%22">Sagie S</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel.<br /><searchLink fieldCode="AU" term="%22Babu+T%22">Babu T</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Weller+C%22">Weller C</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Tabachnik+C%22">Tabachnik C</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Livneh+I%22">Livneh I</searchLink>; Rappaport Technion Cancer Research center, The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel; Institute of Pathology, Rambam Health Care Campus, Haifa 3109601, Israel.<br /><searchLink fieldCode="AU" term="%22Quast+NP%22">Quast NP</searchLink>; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gumpert+N%22">Gumpert N</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Shomuradova+A%22">Shomuradova A</searchLink>; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Raybould+MI%22">Raybould MI</searchLink>; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Levy+R%22">Levy R</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Malko+D%22">Malko D</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Alfia+A%22">Alfia A</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Ben+Lulu+T%22">Ben Lulu T</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Alon+M%22">Alon M</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Herrera+F%22">Herrera F</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Kutuzov+M%22">Kutuzov M</searchLink>; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zerbib+M%22">Zerbib M</searchLink>; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Greenberg+P%22">Greenberg P</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Wasserman-Bartov+T%22">Wasserman-Bartov T</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Benedek+G%22">Benedek G</searchLink>; Faculty of Medicine, Hadassah Hebrew-University Medical Center, Jerusalem 91120, Israel.<br /><searchLink fieldCode="AU" term="%22Levin+Y%22">Levin Y</searchLink>; INCPM, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Stossel+C%22">Stossel C</searchLink>; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.<br /><searchLink fieldCode="AU" term="%22Kamer+I%22">Kamer I</searchLink>; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.<br /><searchLink fieldCode="AU" term="%22Golan+T%22">Golan T</searchLink>; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.<br /><searchLink fieldCode="AU" term="%22Oren+R%22">Oren R</searchLink>; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Shmueli+M%22">Shmueli M</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Bartok+O%22">Bartok O</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Bar+J%22">Bar J</searchLink>; Jusidman Cancer Center, Sheba Medical Center, Ramat Gan 52621, Israel; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Sharett Institute of Oncology, Hadassah Cancer Research Institute and The Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.<br /><searchLink fieldCode="AU" term="%22Dushek+O%22">Dushek O</searchLink>; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Deane+CM%22">Deane CM</searchLink>; Department of Statistics, University of Oxford, OX1 3LB Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Samuels+Y%22">Samuels Y</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: yardena.samuels@weizmann.ac.il.
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