Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats.
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| Title: | Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats. |
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| Authors: | Tonnelé H; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Chen D; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Morillo F; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Garcia-Calleja J; Institute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Chitre AS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Johnson BB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sanches TM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Cheng R; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Gonzalez A; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Kosciolek T; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., George AM; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA., Han W; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Holl K; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Horvath A; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Ishiwari K; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., King CP; Department of Psychology, University at Buffalo, Buffalo, NY, USA., Lamparelli AC; Department of Psychology, University at Buffalo, Buffalo, NY, USA., Martin CD; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., Martinez AG; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Netzley AH; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Tripi JA; Department of Psychology, University at Buffalo, Buffalo, NY, USA., Wang T; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Bosch E; Institute of Evolutionary Biology (CSIC-UPF), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Doris PA; Center for Human Genetics, Institute of Molecular Medicine, McGovern Medical School, University of Texas at Houston, Houston, TX, USA., Stegle O; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Division of Computational Genomics and System Genetics, German Cancer Research Center, Heidelberg, Germany., Chen H; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Sciences Center, Memphis, TN, USA., Flagel SB; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Meyer PJ; Department of Psychology, University at Buffalo, Buffalo, NY, USA., Richards JB; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., Robinson TE; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Solberg Woods LC; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Knight R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science & Engineering, University of California San Diego, La Jolla, CA, USA.; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, La Jolla, CA, San Diego, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu., Baud A; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain. amelie.baud@crg.eu.; Universitat Pompeu Fabra, Barcelona, Spain. amelie.baud@crg.eu. |
| Source: | Nature communications [Nat Commun] 2025 Dec 18; Vol. 16 (1), pp. 10126. Date of Electronic Publication: 2025 Dec 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-66105-z |
