Protective anti-fibrotic effect of liraglutide and Pirfenidone combination therapy on liver fibrosis in rats: effects on autophagy and NLRP3 inflammasome.

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Title: Protective anti-fibrotic effect of liraglutide and Pirfenidone combination therapy on liver fibrosis in rats: effects on autophagy and NLRP3 inflammasome.
Authors: Yousefi Z; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Rajabi R; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran., Karima S; Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran., Nourbakhsh M; Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Nourbakhsh.m@iums.ac.ir.; Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran. Nourbakhsh.m@iums.ac.ir., Lotfi AS; Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad, Nasr, P.O. Box: 14115-111, Tehran, Iran. lotfi_ab@modares.ac.ir.; Iran University of Medical Sciences, Hemmat Highway, P.O. Box: 1419614535, Tehran, Iran. lotfi_ab@modares.ac.ir.
Source: BMC gastroenterology [BMC Gastroenterol] 2025 Dec 18; Vol. 26 (1), pp. 57. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1471-230X
DOI:10.1186/s12876-025-04545-z