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CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease.

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Title: CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease.
Authors: Green NFO; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.; Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Sutton GJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Pérez-Burillo J; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.; RNA Institute, University of New South Wales, Sydney, New South Wales, Australia., Wang J; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Bagot S; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Danon HG; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Walsh K; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Gokool A; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Miles SA; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Yang G; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Herring CA; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.; ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia., Liang Y; BioMedical Machine Learning Lab, The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia., Pfundstein G; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Sytnyk V; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Alinejad-Rokny H; BioMedical Machine Learning Lab, The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia.; UNSW Data Science Hub, University of New South Wales, Sydney, New South Wales, Australia.; Health Data Analytics Program, Centre for Applied Artificial Intelligence, Macquarie University, Sydney, New South Wales, Australia., Lister R; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.; ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia., Rosenbluh J; Cancer Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Gagnon-Bartsch JA; Department of Statistics, University of Michigan, Ann Arbor, MI, USA., Voineagu I; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au.; Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au.; RNA Institute, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au.
Source: Nature neuroscience [Nat Neurosci] 2026 Mar; Vol. 29 (3), pp. 703-716. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease.
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