Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma.

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Title: Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma.
Authors: Aoyama S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Noda T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Akita H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. hakita@gesurg.med.osaka-u.ac.jp., Mukai Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Sasaki K; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Hasegawa S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Yamada D; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Tomimaru Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Asaoka T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Gastroenterological Surgery, Osaka Keisatsu Hospital, Osaka, Japan., Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Kobayashi S; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Shimizu J; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Gastroenterological Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan., Ueyama A; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan.; Biopharmaceutical Research Division, Shionogi & Co., Ltd., Osaka, Japan., Saito T; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Kido K; Department of Pathology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Morii E; Department of Pathology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Wada H; Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan., Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Dec 19; Vol. 75 (1), pp. 20. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1432-0851
DOI:10.1007/s00262-025-04265-z