Targeting IL-1/IRAK1/4 signaling in acute myeloid leukemia stem cells following treatment and relapse.

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Title: Targeting IL-1/IRAK1/4 signaling in acute myeloid leukemia stem cells following treatment and relapse.
Authors: Ho TC; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. tzuho@iu.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. tzuho@iu.edu., LaMere MW; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Kawano H; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Byun DK; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., LaMere EA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Chiu YC; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chen C; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Wang LJ; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wang J; Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA., Ramdas B; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Dokholyan NV; Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.; Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA, USA.; Department of Chemistry, Penn State University, University Park, PA, USA.; Department of Biomedical Engineering, Penn State University, University Park, PA, USA.; Department of Neurology, University of Virginia, Charlottesville, VA, USA., Calvi LM; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Liesveld JL; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Jordan CT; Department of Medicine, University of Colorado, Denver, CO, USA., Singh RK; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Kapur R; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Becker MW; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. beckdarn65@gmail.com.
Source: Leukemia [Leukemia] 2026 Feb; Vol. 40 (2), pp. 293-303. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-025-02816-y