Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.

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Title: Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.
Authors: Jain S; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA. Electronic address: shivangi.jain@adventhealth.com., Solis-Urra P; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Spain; Faculty of Education and Social Sciences, Universidad Andres Bello, Chile., Lesnovskaya A; Department of Psychology, University of Pittsburgh, USA., Wan L; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Molina-Hidalgo C; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Collins A; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Huang H; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA., Sewell KR; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia., Reed R; Department of Psychology, University of Pittsburgh, USA., Rogers RJ; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA., Marsland AL; Department of Psychology, University of Pittsburgh, USA., Grove G; Department of Psychology, University of Pittsburgh, USA., Oberlin LE; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychiatry, Weill Cornell Medicine, NY, USA., Kang C; Department of Psychiatry, University of Pittsburgh, USA., Jakicic JM; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA., Raine L; Department of Psychology, Northeastern University, USA., Mettenburg J; Department of Radiology, University of Pittsburgh, USA., Sparks LM; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; AdventHealth Translational Research Institute, Orlando, USA., Kramer AF; Department of Psychology, Northeastern University, USA; Beckman Institute, University of Illinois, Urbana, USA., Hillman C; Department of Psychology, Northeastern University, USA; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, USA; Center for Cognitive & Brain Health, Northeastern University, USA., McAuley E; Beckman Institute, University of Illinois, Urbana, USA; Department of Health and Kinesiology, University of Illinois, Urbana-Champaign, USA., Burns JM; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA., Vidoni ED; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA., Sutton BP; Beckman Institute, University of Illinois, Urbana, USA; Grainger College of Engineering, Department of Bioengineering, University of Illinois, Urbana-Champaign, USA., Erickson KI; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Feb; Vol. 132, pp. 106223. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2139
DOI:10.1016/j.bbi.2025.106223