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Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.

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Title: Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.
Authors: Jain S; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA. Electronic address: shivangi.jain@adventhealth.com., Solis-Urra P; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Spain; Faculty of Education and Social Sciences, Universidad Andres Bello, Chile., Lesnovskaya A; Department of Psychology, University of Pittsburgh, USA., Wan L; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Molina-Hidalgo C; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Collins A; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA., Huang H; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA., Sewell KR; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia., Reed R; Department of Psychology, University of Pittsburgh, USA., Rogers RJ; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA., Marsland AL; Department of Psychology, University of Pittsburgh, USA., Grove G; Department of Psychology, University of Pittsburgh, USA., Oberlin LE; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychiatry, Weill Cornell Medicine, NY, USA., Kang C; Department of Psychiatry, University of Pittsburgh, USA., Jakicic JM; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA., Raine L; Department of Psychology, Northeastern University, USA., Mettenburg J; Department of Radiology, University of Pittsburgh, USA., Sparks LM; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; AdventHealth Translational Research Institute, Orlando, USA., Kramer AF; Department of Psychology, Northeastern University, USA; Beckman Institute, University of Illinois, Urbana, USA., Hillman C; Department of Psychology, Northeastern University, USA; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, USA; Center for Cognitive & Brain Health, Northeastern University, USA., McAuley E; Beckman Institute, University of Illinois, Urbana, USA; Department of Health and Kinesiology, University of Illinois, Urbana-Champaign, USA., Burns JM; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA., Vidoni ED; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA., Sutton BP; Beckman Institute, University of Illinois, Urbana, USA; Grainger College of Engineering, Department of Bioengineering, University of Illinois, Urbana-Champaign, USA., Erickson KI; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Feb; Vol. 132, pp. 106223. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
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  Data: Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study.
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  Data: <searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA. Electronic address: shivangi.jain@adventhealth.com.<br /><searchLink fieldCode="AU" term="%22Solis-Urra+P%22">Solis-Urra P</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Spain; Faculty of Education and Social Sciences, Universidad Andres Bello, Chile.<br /><searchLink fieldCode="AU" term="%22Lesnovskaya+A%22">Lesnovskaya A</searchLink>; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Molina-Hidalgo+C%22">Molina-Hidalgo C</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Collins+A%22">Collins A</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA.<br /><searchLink fieldCode="AU" term="%22Sewell+KR%22">Sewell KR</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Reed+R%22">Reed R</searchLink>; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+RJ%22">Rogers RJ</searchLink>; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA.<br /><searchLink fieldCode="AU" term="%22Marsland+AL%22">Marsland AL</searchLink>; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Grove+G%22">Grove G</searchLink>; Department of Psychology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Oberlin+LE%22">Oberlin LE</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychiatry, Weill Cornell Medicine, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kang+C%22">Kang C</searchLink>; Department of Psychiatry, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Jakicic+JM%22">Jakicic JM</searchLink>; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, USA.<br /><searchLink fieldCode="AU" term="%22Raine+L%22">Raine L</searchLink>; Department of Psychology, Northeastern University, USA.<br /><searchLink fieldCode="AU" term="%22Mettenburg+J%22">Mettenburg J</searchLink>; Department of Radiology, University of Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Sparks+LM%22">Sparks LM</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; AdventHealth Translational Research Institute, Orlando, USA.<br /><searchLink fieldCode="AU" term="%22Kramer+AF%22">Kramer AF</searchLink>; Department of Psychology, Northeastern University, USA; Beckman Institute, University of Illinois, Urbana, USA.<br /><searchLink fieldCode="AU" term="%22Hillman+C%22">Hillman C</searchLink>; Department of Psychology, Northeastern University, USA; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, USA; Center for Cognitive & Brain Health, Northeastern University, USA.<br /><searchLink fieldCode="AU" term="%22McAuley+E%22">McAuley E</searchLink>; Beckman Institute, University of Illinois, Urbana, USA; Department of Health and Kinesiology, University of Illinois, Urbana-Champaign, USA.<br /><searchLink fieldCode="AU" term="%22Burns+JM%22">Burns JM</searchLink>; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA.<br /><searchLink fieldCode="AU" term="%22Vidoni+ED%22">Vidoni ED</searchLink>; Alzheimer's Disease Research Center, Department of Neurology, The University of Kansas Medical Center, Kansas City, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+BP%22">Sutton BP</searchLink>; Beckman Institute, University of Illinois, Urbana, USA; Grainger College of Engineering, Department of Bioengineering, University of Illinois, Urbana-Champaign, USA.<br /><searchLink fieldCode="AU" term="%22Erickson+KI%22">Erickson KI</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, USA; Department of Psychology, University of Pittsburgh, USA.
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  Data: <searchLink fieldCode="JN" term="%228800478%22">Brain, behavior, and immunity</searchLink> [Brain Behav Immun] 2026 Feb; Vol. 132, pp. 106223. <i>Date of Electronic Publication: </i>2025 Dec 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8800478 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2139 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208891591%22">08891591 </searchLink><i>NLM ISO Abbreviation: </i>Brain Behav Immun <i>Subsets: </i>MEDLINE
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