SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia.

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Title: SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia.
Authors: Sawada T; Lieber Institute for Brain Development, Baltimore, MD, USA. Tomoyo.Sawada@libd.org.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Tomoyo.Sawada@libd.org., Feltrin AS; Lieber Institute for Brain Development, Baltimore, MD, USA., Wang Y; Lieber Institute for Brain Development, Baltimore, MD, USA., Araujo B; Lieber Institute for Brain Development, Baltimore, MD, USA., McCord AE; Lieber Institute for Brain Development, Baltimore, MD, USA., Giles HH; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Han S; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Radulescu E; Lieber Institute for Brain Development, Baltimore, MD, USA., Chen Q; Lieber Institute for Brain Development, Baltimore, MD, USA., Qamar B; Lieber Institute for Brain Development, Baltimore, MD, USA., R Barbosa A; Lieber Institute for Brain Development, Baltimore, MD, USA., Jacomini RS; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lorenzetti APR; Lieber Institute for Brain Development, Baltimore, MD, USA., Dimitrova V; University Obstetrics and Gynecology Hospital 'Maichin Dom', Medical University of Sofia, Sofia, Bulgaria., Kaneva R; Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University of Sofia, Sofia, Bulgaria., Vladimirov V; Department of Psychiatry, College of Medicine, University of Arizona, Phoenix, AZ, USA., Kleinman JE; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hyde TM; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Weinberger DR; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Paquola ACM; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Erwin JA; Lieber Institute for Brain Development, Baltimore, MD, USA. Jennifer.erwins@gmail.com.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Jennifer.erwins@gmail.com.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Jennifer.erwins@gmail.com.
Source: Nature communications [Nat Commun] 2025 Dec 20; Vol. 17 (1), pp. 461. Date of Electronic Publication: 2025 Dec 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-67154-0