Tubule-derived CCN1 drives renal repair via αvβ5-STAT6-ARG1-dependent reprogramming of macrophages.

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Title: Tubule-derived CCN1 drives renal repair via αvβ5-STAT6-ARG1-dependent reprogramming of macrophages.
Authors: Zhang N; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Li C; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.; Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Xin Y; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Song Z; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Li T; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Zhao R; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Gu M; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Xu L; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Wang Y; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Man X; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Che L; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Liu H; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China., Guan C; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. 2020015006@qdu.edu.cn., Xu Y; Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. xuyan@qdu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2025 Dec 21; Vol. 17 (1), pp. 115. Date of Electronic Publication: 2025 Dec 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-025-08340-2