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TROP-2 Promotes Cell Proliferation via the AKT-Mediated PKCα Pathway and Is a Novel Target for Antibody-Drug Conjugates in Penile Carcinoma.

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Title: TROP-2 Promotes Cell Proliferation via the AKT-Mediated PKCα Pathway and Is a Novel Target for Antibody-Drug Conjugates in Penile Carcinoma.
Authors: Tang Y; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Situ M; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Wu Z; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Wang Y; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Deng X; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Liu Z; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Guo S; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Zhou Q; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Yuan G; Department of Urology Oncological Surgery, Chongqing University Cancer Hospital, Chongqing, 400030, China., Tan X; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China., Yao K; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.; State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China.; Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China.
Source: Oncology research [Oncol Res] 2025 Nov 27; Vol. 33 (12), pp. 3973-3989. Date of Electronic Publication: 2025 Nov 27 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1555-3906
DOI:10.32604/or.2025.066184