Gamma-hydroxybutyric acid (GHB) derivatization with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC): LC-HRAM-Orbitrap-MS characterization of GHB and deuterated GHB derivatives and application to blood, urine, and hair analysis.

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Title: Gamma-hydroxybutyric acid (GHB) derivatization with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC): LC-HRAM-Orbitrap-MS characterization of GHB and deuterated GHB derivatives and application to blood, urine, and hair analysis.
Authors: Frison G; Laboratory of Clinical and Forensic Toxicology, DMPO Department, AULSS 3, Venice, Italy. giampietro.frison@aulss3.veneto.it., Negro A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy., Zancanaro F; Laboratory of Clinical and Forensic Toxicology, DMPO Department, AULSS 3, Venice, Italy. giampietro.frison@aulss3.veneto.it., Frasson S; Laboratory of Clinical and Forensic Toxicology, DMPO Department, AULSS 3, Venice, Italy. giampietro.frison@aulss3.veneto.it., Tedeschi G; Laboratory of Clinical and Forensic Toxicology, DMPO Department, AULSS 3, Venice, Italy. giampietro.frison@aulss3.veneto.it., Vigato C; Laboratory of Clinical and Forensic Toxicology, DMPO Department, AULSS 3, Venice, Italy. giampietro.frison@aulss3.veneto.it., Miolo G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Source: Analytical methods : advancing methods and applications [Anal Methods] 2026 Jan 15; Vol. 18 (2), pp. 446-465. Date of Electronic Publication: 2026 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: RSC Pub Country of Publication: England NLM ID: 101519733 Publication Model: Electronic Cited Medium: Internet ISSN: 1759-9679 (Electronic) Linking ISSN: 17599660 NLM ISO Abbreviation: Anal Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1759-9679
DOI:10.1039/d5ay01461a