Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.
Saved in:
| Title: | Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk. |
|---|---|
| Authors: | Wang Y; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; ReVacc, Inc., Cambridge, MA, USA., Galkin A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Shang X; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Marin A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Jin S; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Ye TJ; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Bale S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Chiang CI; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Chowdhury A; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Chenine AL; Integrated BioTherapeutics, Inc., Rockville, MD, USA., Turonis A; Integrated BioTherapeutics, Inc., Rockville, MD, USA., Greenhouse J; BIOQUAL, Inc., Rockville, MD, USA., Stone R; BIOQUAL, Inc., Rockville, MD, USA., Wear J; BIOQUAL, Inc., Rockville, MD, USA., Kar S; BIOQUAL, Inc., Rockville, MD, USA., Andersen H; BIOQUAL, Inc., Rockville, MD, USA., Huang YS; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Vanlandingham DL; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Higgs S; Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA., Lapidus RG; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Fuerst T; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA., Weber DJ; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Center for Biomolecular Therapeutics, Rockville, MD, USA.; Center for Biomolecular Therapeutic, Baltimore, MD, USA., Wyatt RT; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Iffland C; OmniAb, Inc., Emeryville, CA, USA., Pierson TC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Andrianov AK; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA., Pozharski E; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. epozhars@umd.edu.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. epozhars@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. epozhars@umd.edu., Li Y; Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. yuxingli@umd.edu.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutics, Rockville, MD, USA. yuxingli@umd.edu.; Center for Biomolecular Therapeutic, Baltimore, MD, USA. yuxingli@umd.edu. |
| Source: | Nature communications [Nat Commun] 2025 Dec 22; Vol. 16 (1), pp. 11558. Date of Electronic Publication: 2025 Dec 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-025-67447-4 |
