Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh syndrome mice.

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Title: Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh syndrome mice.
Authors: Biswas SR; Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, VA, 24016, USA., Tomsick PL; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Kelly C; Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, VA, 24016, USA., Lester BA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Milner JP; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Henry SN; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Soto Y; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Brindley S; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., DeFoor N; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Morton PD; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. pmorton@vt.edu., Pickrell AM; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. alicia.pickrell@vt.edu.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Feb; Vol. 18 (2), pp. 677-701. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-025-00367-4