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Antibody concentration and function following SARS-CoV-2 vaccination decrease with age in adults and children with Down syndrome.

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Title: Antibody concentration and function following SARS-CoV-2 vaccination decrease with age in adults and children with Down syndrome.
Authors: Streng BMM; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands., Hensen LCM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Delemarre EM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Binnendijk RS; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands., Smits G; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands., den Hartog G; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands; Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, the Netherlands., van der Klis FR; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands., de Vries E; Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, the Netherlands; Jeroen Bosch Academy Research, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands., Burger JA; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands., Coppus AMW; Department for Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands., Weijerman ME; Department of Pediatrics, Alrijne Hospital, Leiderdorp, the Netherlands., Lamberts R; Foundation 'Stichting Down Syndroom', Meppel, the Netherlands., de Graaf G; Foundation 'Stichting Down Syndroom', Meppel, the Netherlands., Bont LJ; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands., Wildenbeest JG; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: J.G.wildenbeest@umcutrecht.nl.
Source: Vaccine [Vaccine] 2026 Feb 15; Vol. 73, pp. 128079. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antibody concentration and function following SARS-CoV-2 vaccination decrease with age in adults and children with Down syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Streng+BMM%22">Streng BMM</searchLink>; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hensen+LCM%22">Hensen LCM</searchLink>; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Delemarre+EM%22">Delemarre EM</searchLink>; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Binnendijk+RS%22">Binnendijk RS</searchLink>; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Smits+G%22">Smits G</searchLink>; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22den+Hartog+G%22">den Hartog G</searchLink>; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands; Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Klis+FR%22">van der Klis FR</searchLink>; Center for Immunology of Infectious Diseases and vaccines, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vries+E%22">de Vries E</searchLink>; Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, the Netherlands; Jeroen Bosch Academy Research, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+JA%22">Burger JA</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gils+MJ%22">van Gils MJ</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Coppus+AMW%22">Coppus AMW</searchLink>; Department for Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Weijerman+ME%22">Weijerman ME</searchLink>; Department of Pediatrics, Alrijne Hospital, Leiderdorp, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lamberts+R%22">Lamberts R</searchLink>; Foundation 'Stichting Down Syndroom', Meppel, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Graaf+G%22">de Graaf G</searchLink>; Foundation 'Stichting Down Syndroom', Meppel, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bont+LJ%22">Bont LJ</searchLink>; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wildenbeest+JG%22">Wildenbeest JG</searchLink>; Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: J.G.wildenbeest@umcutrecht.nl.
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  Data: <searchLink fieldCode="JN" term="%228406899%22">Vaccine</searchLink> [Vaccine] 2026 Feb 15; Vol. 73, pp. 128079. <i>Date of Electronic Publication: </i>2025 Dec 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8406899 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2518 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220264410X%22">0264410X </searchLink><i>NLM ISO Abbreviation: </i>Vaccine <i>Subsets: </i>MEDLINE
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