Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease.

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Title: Anti-BCMA-CAR-IL15 natural killer cells prevent multiple myeloma growth in the bone marrow but allow subsequent emergence of extramedullary disease.
Authors: Kaczmarek S; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Jo D; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Ghaziasgar S; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Marr B; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Berton S; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Wang L; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; The Ottawa Institute of Systems Biology (OISB), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Arbabi Ghahroudi M; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Human Health Therapeutics Research Centre (HHT), National Research Council of Canada, Ottawa, ON, Canada., Jang M; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, South Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, South Korea., Visram A; Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, ON, Canada., McComb S; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; The Ottawa Institute of Systems Biology (OISB), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Human Health Therapeutics Research Centre (HHT), National Research Council of Canada, Ottawa, ON, Canada., Lee SH; Department of Biochemistry, Microbiology, and Immunology (BMI), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Infection, Immunity, and Inflammation (CI3), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; The Ottawa Institute of Systems Biology (OISB), Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Electronic address: seunglee@uottawa.ca.
Source: Cancer letters [Cancer Lett] 2026 Feb 28; Vol. 639, pp. 218235. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7980
DOI:10.1016/j.canlet.2025.218235