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Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation.

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Title: Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation.
Authors: Boyer TL; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: boyer.t@northeastern.edu., Hakim B; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: hakim.bi@northeastern.edu., Childress L; Graduate Program for Interdisciplinary Biomedical Sciences, UAMS, Little Rock, AR, United States. Electronic address: lchildress@uams.edu., Baby HM; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: baby.h@northeastern.edu., Porter RM; Department of Internal Medicine, UAMS, Little Rock, AR, United States; Dept. of Orthopaedic Surgery, UAMS, Little Rock, AR, United States. Electronic address: rmporter@uams.edu., Bajpayee AG; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: a.bajpayee@northeastern.edu.
Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 Apr; Vol. 34 (4), pp. 563-574. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Boyer+TL%22">Boyer TL</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: boyer.t@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Hakim+B%22">Hakim B</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: hakim.bi@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Childress+L%22">Childress L</searchLink>; Graduate Program for Interdisciplinary Biomedical Sciences, UAMS, Little Rock, AR, United States. Electronic address: lchildress@uams.edu.<br /><searchLink fieldCode="AU" term="%22Baby+HM%22">Baby HM</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: baby.h@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Porter+RM%22">Porter RM</searchLink>; Department of Internal Medicine, UAMS, Little Rock, AR, United States; Dept. of Orthopaedic Surgery, UAMS, Little Rock, AR, United States. Electronic address: rmporter@uams.edu.<br /><searchLink fieldCode="AU" term="%22Bajpayee+AG%22">Bajpayee AG</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, United States. Electronic address: a.bajpayee@northeastern.edu.
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  Data: <searchLink fieldCode="JN" term="%229305697%22">Osteoarthritis and cartilage</searchLink> [Osteoarthritis Cartilage] 2026 Apr; Vol. 34 (4), pp. 563-574. <i>Date of Electronic Publication: </i>2025 Dec 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders+For+The+Osteoarthritis+Research+Society%22">W.B. Saunders For The Osteoarthritis Research Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9305697 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-9653 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210634584%22">10634584 </searchLink><i>NLM ISO Abbreviation: </i>Osteoarthritis Cartilage <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.joca.2025.12.018
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        Text: English
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      – TitleFull: Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation.
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              Text: 2026 Apr
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