Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR.
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| Title: | Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR. |
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| Authors: | Luoying W; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China., Xingcheng Y; Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China., Donghang C; Department of Cadre Ward, The First Hospital of Jilin University, Changchun, China., Mengtuan L; Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China., Ping W; Department of Otolaryngology-Head and Neck Surgery, First Hospital of Jilin University, Changchun, China., Lijuan Z; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China.; Jilin Medical University, Jilin, China., Yupeng L; Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, China., Tianyi Z; Institute of Changbai Mountain Biology Germplasm Resources, Tonghua Normal University, Tonghua Jilin, China., Hongyu C; School of Software, Tsinghua University, Beijing, China.; School of Computer Science, Hangzhou Dianzi University, Hangzhou, China., Song W; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China., Zijun Z; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China., Hanyu Z; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China., Shengchao C; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China., Cong F; Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China., Xiaoyun S; Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, China. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Dec 11; Vol. 16, pp. 1694985. Date of Electronic Publication: 2025 Dec 11 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1694985 |
