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Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.

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Title: Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.
Authors: Bopp V; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., LeeBae J; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Oeckl P; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Kühlwein JK; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Grozdanov V; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Kiechle M; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Mayer B; Institute of Epidemiology and Medical Biometry, Ulm University, 89075 Ulm, Germany., Möhrle B; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany., Geiger H; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany., Danzer KM; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.
Source: IScience [iScience] 2025 Nov 25; Vol. 28 (12), pp. 114217. Date of Electronic Publication: 2025 Nov 25 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.114217