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Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.

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Title: Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.
Authors: Bopp V; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., LeeBae J; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Oeckl P; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Kühlwein JK; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Grozdanov V; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Kiechle M; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany., Mayer B; Institute of Epidemiology and Medical Biometry, Ulm University, 89075 Ulm, Germany., Möhrle B; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany., Geiger H; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany., Danzer KM; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.
Source: IScience [iScience] 2025 Nov 25; Vol. 28 (12), pp. 114217. Date of Electronic Publication: 2025 Nov 25 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.
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  Data: <searchLink fieldCode="AU" term="%22Bopp+V%22">Bopp V</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22LeeBae+J%22">LeeBae J</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Oeckl+P%22">Oeckl P</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kühlwein+JK%22">Kühlwein JK</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Grozdanov+V%22">Grozdanov V</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kiechle+M%22">Kiechle M</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer+B%22">Mayer B</searchLink>; Institute of Epidemiology and Medical Biometry, Ulm University, 89075 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Möhrle+B%22">Möhrle B</searchLink>; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Geiger+H%22">Geiger H</searchLink>; Institute of Molecular Medicine, Ulm University, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Danzer+KM%22">Danzer KM</searchLink>; Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Nov 25; Vol. 28 (12), pp. 114217. <i>Date of Electronic Publication: </i>2025 Nov 25 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Nov 25
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