Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells.

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Title: Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells.
Authors: Kozlov AM; Department of Biology, Western University, London, ON N6A 5B7, Canada., Leung ZCL; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., Wilson RB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., Bhangal S; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., Nygard K; Biotron Integrated Microscopy, Western University, London, ON N6A 5B7, Canada., Powell AM; Department of Biology, Western University, London, ON N6A 5B7, Canada., Borradaile NM; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., Betts DH; Department of Biology, Western University, London, ON N6A 5B7, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.; Genetics and Development Division, The Children's Health Research Institute, Lawson Health Research Institute, London, ON N6C 2V5, Canada.; Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada., Cumming RC; Department of Biology, Western University, London, ON N6A 5B7, Canada.; Genetics and Development Division, The Children's Health Research Institute, Lawson Health Research Institute, London, ON N6C 2V5, Canada.
Source: Biology open [Biol Open] 2026 Jan 01; Vol. 15 (1). Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2046-6390
DOI:10.1242/bio.062432